
香港:当华盛顿和北京在前沿科技领域争夺主导地位时,有一个领域竞争不应妨碍合作:创新药物。北京最新的生物技术领域五年规划详细阐述了该国希望在全球范围内引领该领域的愿景。作为一份产业蓝图,它不同寻常地附带了数字目标。
HONG KONG: As Washington and Beijing tussle for dominance in frontier technologies, there’s one area in which competition shouldn’t preclude collaboration: innovative medicines. Beijing’s latest five-year plan for the biotechnology sector details how the country wants to lead the field globally. Unusually for an industrial blueprint, it comes with numeric targets.
到2030年,中国制药商的竞争力预计将实现“重大飞跃”,新药销售额年增长20%。制药公司力争开发出全球至少25%的“首创”药物,即以全新方式治疗疾病的药物。它们还预计至少推出五款年销售额超过10亿美元的“重磅炸弹”疗法。
By 2030, Chinese drugmakers are expected to have made a“major leap” in competitiveness with sales of new medications growing 20 per cent annually. Pharmaceutical companies aim to develop at least 25 per cent of the world’s first-in-class medicines, which are drugs that work in an entirely new way to treat a condition. They’re also expected to have originated at least five blockbuster therapies with sales of more than US$1 billion a year.
押注中国研发 这些雄心并非看上去那么不切实际。数十年的政策支持,包括教育投资,已帮助中国从药物开发的追随者转变为日益肥沃的创新源泉。
BETTING ON CHINESE RESEARCH These ambitions aren’t as farfetched as they might seem. Decades of policy support, including investment in education, have helped turn the country into an increasingly fertile source of innovation from a follower in drug development.
大型制药公司已注意到这一点。为了在大量利润丰厚的专利到期前补充产品管线,全球企业掀起了一轮收购热潮,尤其是在中国擅长的癌症和肥胖治疗等领域。过去五年间,海外药物许可交易的价值飙升逾十倍,达到创纪录的1340亿美元。
Big Pharma has taken notice. To replenish their pipeline before a slew of lucrative patents expire, global companies have gone on a shopping spree, particularly in areas such as cancer and obesity treatments where China excels. Over the past five years, the value of overseas drug-licensing deals has surged more than 10-fold to a record US$134 billion.
近期的交易彰显了国际需求的强劲。上周,诺和诺德同意向江苏恒瑞医药支付最高26亿美元,以获得一款每周只需服用一次的实验性减肥药的权益。这笔交易因其高达3亿美元的首付款而引人注目,而该疗法尚未有人体试验数据。
Recent deals illustrate the strength of international demand. Last week, Novo Nordisk agreed to pay Jiangsu Hengrui Pharmaceuticals as much as US$2.6 billion for rights to an experimental obesity pill that can be taken just once a week. The deal stood out for its hefty US$300 million upfront payment for a therapy that has no human trial data.
如此大规模的提前投资,充分体现了西方制药企业如今对中国科研实力的重视。目前市面上两款主流的口服GLP-1减肥药分别由诺和诺德和礼来公司生产,均需每日服用一次;因此,若能开发出每周仅需服用一次的替代药物,显然具备巨大的商业价值。10月2日周五,诺华又与艾博生物达成了一项规模更大的合作协议:为获取一款针对自身免疫性疾病的实验性mRNA疗法,诺华将支付最高达78亿美元的费用。
The willingness to place such a large bet so early demonstrates how Western drugmakers now value Chinese research. Because the two mainstream oral GLP-1 weight-loss drugs (from Novo and Eli Lilly) require daily dosing, a successful weekly alternative holds obvious commercial appeal. On Friday (Oct 2), Novartis struck an even bigger deal with Abogen Biosciences, paying as much as US$7.8 billion for an experimental mRNA treatment for autoimmune diseases.
这一成功局面却让美国政府陷入两难境地。有观点认为,如果大型制药企业选择引进价格更低的中国药物分子,而非资助本土初创企业,那么美国生物技术产业所需的资金与专业人才便会大量流失。这一逻辑与美国对先进半导体的出口管制措施类似——后者旨在防止美国设计的芯片被用于推动中国人工智能发展,或阻止中国汽车制造商进入美国市场。
That success has created a dilemma for Washington. The argument goes that if pharma giants can license cheaper Chinese molecules rather than funding American startups, it will drain capital and expertise from the US biotech ecosystem. The logic resembles the US government’s export controls on advanced semiconductors, which are intended to prevent US-designed chips from helping accelerate China’s AI development or curb Chinese carmakers’ access to the US market.
目前,美国已通过《生物安全法案》试图降低对中国生物技术企业的依赖,该法案禁止联邦机构与被列入名单的中国企业开展合作。今年又有一项获得两党支持的提案被提出,该提案旨在进一步限制目前正吸引众多西方药企参与的此类授权合作。
The US has already sought to cut its reliance on Chinese biotechnology companies through the Biosecure Act, which restricts federal agencies from working with designated companies. A bipartisan proposal introduced this year would go further, potentially limiting the kind of licensing deals now attracting Western drugmakers.
实施此类限制实属错误之举。创新药物的研发无法像半导体、电动汽车或大型语言模型那样以零和博弈的模式来考量——在这些领域,一方的成功往往意味着另一方的失利。而制药行业本质上具有高度协作性,尤其是在生命科学领域。一款救命药物的来源地远不如患者能否顺利获得该药物来得重要。
RESTRICTIONS WILL BE A MISTAKE But that would be a mistake. Novel medicines can’t be treated in the same zero-sum way as semiconductors, electric vehicles or large language models where one competitor’s win comes at the expense of the other. The industry is inherently collaborative, especially in life sciences. The origin of a lifesaving treatment matters far less than whether patients can get access to it.
美国财政部似乎明白其中的区别。据路透社近日报道,该部门正在考虑制定相关规则,在限制涉及病原体或可能被武器化的技术投资的同时,保留美国制药企业从中国公司引进创新疗法的权利。这一做法合情合理。华盛顿方面确实有充分理由防止具有潜在危险性的技术落入对手手中,但这并不意味着上海的任何科研成果都会构成国家安全威胁。
The US Treasury Department appears to understand the distinction. It’s considering rules that would preserve American drugmakers’ ability to license innovative treatments from Chinese companies, Reuters reported recently, while restricting investments involving pathogens or technology that could be weaponised. It’s a sensible approach. Washington has a strong incentive to keep potentially dangerous technologies out of an adversary’s hands, but that doesn’t mean every discovery from Shanghai is a national security threat.
诚然,凭借更充裕的资金以及数量众多的国际科研人才,美国理应努力在生物技术领域赶超中国。正因如此,特朗普政府最好放弃进一步削减美国顶尖科研机构经费的打算——这些机构的资金支持着能够催生商业突破的基础研究,也吸引着全球顶尖科研人才汇聚美国。此外,华盛顿还可继续推进建设独立于中国的仿制药原料供应链计划。
To be sure, the US absolutely should be trying to beat China in the biotech race with its greater access to capital and a larger cohort of international scientists. That’s why the Trump administration would be wise to back away from further cuts to America’s top science agencies, whose funding supports the basic research that can ultimately produce commercial breakthroughs, and which draws top scientific talent to the country. Washington could also press ahead with plans to create a supply chain that is independent of China for producing raw materials needed to make generic medicines.
确保本土制药能力、维护美国创新实力有其合理之处。但限制外国药品进入美国绝非实现该目标的良策。华盛顿应当努力超越中国,而非无视中国的创新成果。
There are legitimate reasons to ensure domestic pharmaceutical capacity and preserve US innovation. But restricting access to foreign medicines is not the way to accomplish that goal. Washington should try to outdo China, not ignore its innovations.