US Secretary of State Marco Rubio arrived in Samarkand, Uzbekistan, on Sunday evening ahead of talks with representatives of five Central Asian countries, as Washington seeks to expand diplomatic, economic and security cooperation with the region.

Rubio will attend a ministerial meeting under the C5+1 format, bringing together the United States and Uzbekistan, Kazakhstan, Kyrgyzstan, Tajikistan and Turkmenistan. He is also scheduled to hold bilateral talks with senior officials from all five countries.

The visit has a significant commercial dimension. According to the US State Department, Rubio is accompanied by a delegation of more than 200 American business leaders, with discussions expected to focus on opportunities for trade, investment and economic cooperation.

Speaking to reporters at Joint Base Andrews on Saturday, before leaving Washington, Rubio was asked why he had chosen to visit Uzbekistan while several international crises demand American diplomatic attention."

This is an important relationship," Rubio said, explaining that the timing had been chosen to bring together the foreign ministers of all five Central Asian countries."

One of the things that suffers is the strategic business," he said, referring to the tendency for diplomatic visits to focus on immediate crises. "But there's countries you'd like to get to because we want to build our relationships with them."C5+1: From Samarkand to the White HouseThe C5+1 framework was established in Samarkand in November 2015, when then-US Secretary of State John Kerry met his counterparts from the five Central Asian republics.

The dialogue subsequently expanded to presidential level, with meetings hosted by Joe Biden in 2023 and Donald Trump in November 2025. The most recent summit in Washington placed particular emphasis on trade, investment and critical minerals.

According to the US Department of Commerce, more than $25bn (approximately €22bn) in commercial agreements and commitments were announced during the November 2025 C5+1 meetings, covering aviation, agricultural equipment, railway infrastructure and mineral development. These included agreements at different stages of development rather than investments already completed. Trade, investment and strategic cooperationKazakhstan and Uzbekistan are among Washington's main economic partners in the region. According to US government figures, bilateral trade in goods and services reached $7.1bn (approxiametely €6.3bn) with Kazakhstan and $1.7bn (€1.5bn) with Uzbekistan in 2025, while American companies have also announced agreements covering aircraft, agricultural machinery and mineral development.

Central Asia offers Washington opportunities to diversify critical mineral supply chains and develop partnerships in energy, transport infrastructure and technology.

The region has substantial oil, natural gas and uranium resources, alongside deposits of other minerals used in manufacturing, advanced technologies and energy systems.

For Central Asian governments, closer ties with the United States offer additional sources of investment, technology and access to international markets, while they maintain extensive economic relationships with Russia and China. The European Union is also seeking closer economic ties with Central Asia.

At a summit in Samarkand in April 2025, Brussels announced a €12bn Global Gateway investment package covering transport, critical raw materials, energy and digital connectivity. The American delegation includes representatives of companies such as Boeing, Citibank and Franklin Templeton. American development finance and export credit institutions are also expected to participate in business discussions. Security cooperation is another element of the agenda, with US officials identifying counterterrorism as an area for closer cooperation with some countries in the region.

Bilateral talks with UzbekistanThe programme also includes the first round of an expanded strategic partnership dialogue between Rubio and Uzbekistan's Foreign Minister Bakhtiyor Saidov on Monday. According to the Uzbek Foreign Ministry, the discussions will cover political relations, trade, investment and regional and international developments. On 16 October, President Shavkat Mirziyoyev met US Special Envoy for South and Central Asia Sergio Gor to review preparations for Rubio's visit, the C5+1 meeting and the second session of the Uzbekistan–US Business and Investment Council.

President Mirziyoyev is scheduled to attend the Council's meeting in Samarkand on Monday. The Council, co-chaired by Saida Mirziyoyeva, Head of Uzbekistan's Presidential Administration, and Sergio Gor, was established to promote bilateral investment, commercial partnerships and joint projects.

Security has been tightened in Samarkand, where Uzbekistan's Interior Ministry has announced temporary traffic restrictions on roads leading into the city and several central streets from 18 to 22 October. Following his meetings in Uzbekistan, Rubio is scheduled to travel to India, visiting Mumbai and Jamnagar for discussions with government officials and business leaders, including talks on trade and energy cooperation. His Asian tour is expected to conclude on Thursday.